Stem cell transplantation yog ib qho kev kho mob tseem ceeb rau cov kab mob hematological, kev tiv thaiv kab mob, thiab qee cov qog nqaij hlav malignant. Txawm li cas los xij, cov neeg mob nyob rau hauv lub xeev tsis yooj yim heev tom qab kev phais, nws yuav ua rau muaj teeb meem xws li kev kis kab mob, cov ntaub so ntswg puas, thiab kev ua haujlwm qeeb ntawm hematopoietic. Raws li kev kho mob lub cev, hyperbaric oxygen therapy muab siab - concentration oxygen nyob rau hauv ib puag ncig hyperbaric, uas tuaj yeem daws tau ntau yam teeb meem tom qab kev phais thiab nteg lub hauv paus ruaj khov rau cov neeg mob kev kho mob. Nws qhov tsim nyog yog feem ntau cuam tshuam hauv cov ntsiab lus hauv qab no.
I. Accelerate Hematopoietic Function Reconstruction thiab Shorten Recovery Cycle
Tom qab hloov cov qia cell, tus neeg mob cov pob txha pob txha hematopoietic microenvironment puas lawm, thiab colonization, proliferation, thiab txawv peev xwm ntawm hematopoietic qia hlwb raug txo, uas yooj yim ua rau myelosuppressive cov tsos mob xws li agranulocytosis thiab thrombocytopenia. Qhov no tsis yog tsuas yog ua rau muaj kev pheej hmoo ntawm kev kis kab mob thiab los ntshav tab sis tseem ua rau lub sijhawm nyob hauv tsev kho mob ntev. Hyperbaric oxygen tuaj yeem ua rau kom cov pa oxygen hauv cov ntshav nce ntxiv, muab cov pa oxygen txaus rau cov hlwb stromal thiab hematopoietic qia hlwb hauv cov pob txha pob txha hematopoietic microenvironment. Stromal hlwb tau txhim kho kev ua si hauv ib puag ncig hyperoxic thiab tuaj yeem zais ntau yam kev loj hlob ntawm hematopoietic (xws li granulocyte colony-stimulating factor thiab erythropoietin), txhawb kev colonization thiab proliferation ntawm hematopoietic qia hlwb. Nyob rau tib lub sijhawm, hyperoxia tuaj yeem txhim kho cov ntshav ncig hauv cheeb tsam hauv cov pob txha pob txha, txo qis kev puas tsuaj rau cov ntaub so ntswg hematopoietic, ua kom cov pob txha pob txha hematopoietic muaj nuj nqi, pab cov neeg mob tawm ntawm agranulocytosis thiab thrombocytopenia theem sai dua, thiab txo qhov tshwm sim ntawm kev tso ntshav thiab lwm yam teeb meem.
II. Tiv thaiv kev kis kab mob thiab txo qis kev pheej hmoo kis mob tom qab phais
Vim muaj kev tiv thaiv kab mob hnyav heev tom qab kev phais mob (kev tua cov kab mob hauv lub cev los ntawm kev kho mob thiab kev tsim cov hlwb tsis txaus los ntawm myelosuppression), cov neeg mob muaj kev pheej hmoo ntawm kev kis kab mob, thiab kis tau yooj yim mus rau mob ntsws loj, sepsis, thiab lwm yam, ua rau muaj kev phom sij rau lub neej. Hyperbaric oxygen therapy exerts los tiv thaiv - kis mob nyob rau hauv ob yam: ntawm ib sab, siab - pa oxygen muaj peev xwm ncaj qha inhibit qhov kev loj hlob thiab kev loj hlob ntawm cov kab mob anaerobic thiab qee cov kab mob aerobic, tshwj xeeb tshaj yog muaj kev cuam tshuam tseem ceeb ntawm cov kab mob anaerobic uas yuav tshwm sim tom qab phais (xws li perianal abscess thiab mob txhab); Ntawm qhov tod tes, cov pa oxygen txaus tuaj yeem txhim kho cov haujlwm phagocytic thiab cov kab mob bactericidal ntawm lub cev tiv thaiv kab mob xws li neutrophils thiab macrophages. Nyob rau hauv ib puag ncig hyperoxic, lub cev tiv thaiv kab mob tuaj yeem tshem tawm cov kab mob zoo dua, txhawb kev tshem tawm cov khoom pov tseg ntawm cov kab mob metabolic ntawm qhov chaw mob, txo cov lus teb inflammatory, thiab tiv thaiv kev kis kab mob. Cov kev tshawb fawb soj ntsuam tau pom tias kev kho mob hyperbaric oxygen tuaj yeem txo qhov tshwm sim ntawm kev mob ntsws ntsws thiab mob perianal hauv cov neeg mob hloov cov qia cell thiab ua kom lub voj voog kho kab mob luv.
III. Kho cov ntaub so ntswg puas thiab txo cov teeb meem
Preoperative conditioning regimens (chemotherapy, radiotherapy) thiab kev phais mob rau kev hloov pauv ntawm cov qia tuaj yeem ua rau muaj kev puas tsuaj rau cov ntaub so ntswg thiab cov kabmob xws li plab hnyuv mucosa, daim tawv nqaij mucosa, thiab daim siab, yooj yim ua rau muaj teeb meem xws li mob qhov ncauj, plab hnyuv, thiab daim siab puas tsuaj, uas cuam tshuam rau cov neeg mob noj qab haus huv thiab noj qab haus huv. Hyperbaric oxygen tuaj yeem nkag mus rau hauv lub vascular barrier, ncav cuag cov ntaub so ntswg puas ncaj qha, nce cov ntaub so ntswg hauv zos oxygen ib feem ntawm lub siab, thiab txhawb kev tsim kho thiab kho cov kab mob mucosal puas thiab hepatocytes. Rau cov kab mob ntawm qhov ncauj thiab plab hnyuv mucosal puas tsuaj, hyperoxia tuaj yeem ua kom cov kab mob mucosal epithelial loj hlob tuaj, txhawb kev kho qhov txhab, txo cov tsos mob xws li mob thiab los ntshav, thiab pab cov neeg mob rov qab noj zaub mov kom sai li sai tau los xyuas kom muaj kev noj qab haus huv. Rau lub siab puas tsuaj, cov pa oxygen txaus tuaj yeem txo cov hepatocyte edema thiab necrosis, txhawb kev kho hepatocyte, thiab txo qhov kev pheej hmoo ntawm daim siab tsis ua haujlwm. Tsis tas li ntawd, hyperbaric oxygen tuaj yeem txhim kho qhov chaw kho mob ntawm daim tawv nqaij qhov txhab (xws li central venous catheter puncture sites thiab phais incisions), txo qhov tshwm sim ntawm qhov txhab kab mob thiab kev kho mob qeeb.
IV. Txhim kho Microcirculatory Disorders thiab alleviate Ischemic -Hypoxic puas
Cov tshuaj chemotherapeutic thiab radiotherapy nyob rau hauv cov kev kho mob yuav ua rau vascular endothelial hlwb, ua rau vasospasm thiab tsis txaus microcirculatory perfusion, uas nyob rau hauv lem ua rau ischemic -hypoxic puas rau cov ntaub so ntswg, feem ntau tshwm sim nyob rau hauv lub raum, plawv, paj hlwb, thiab lwm yam, manifested li txawv txav lub raum kev ua haujlwm, thiab lwm yam. Hyperbaric oxygen tuaj yeem nthuav dav microvessels, txo cov ntshav viscosity, txhim kho microcirculatory perfusion, ua kom cov pa oxygen rau cov ntaub so ntswg ischemic, txo cov vascular endothelial cell puas, inhibit dawb radical tiam, thiab txo ischemia-reperfusion raug mob. Rau lub raum, nws tuaj yeem ua rau lub raum parenchymal ischemia thiab hypoxia thiab tiv thaiv lub raum ua haujlwm; rau lub paj hlwb, nws tuaj yeem txhim kho paj hlwb cov ntaub so ntswg oxygen, txo cov neurotoxicity tshwm sim los ntawm kev txias, thiab txo qhov tshwm sim ntawm kev paub txog kev paub tsis meej thiab peripheral neuropathy; rau lub plawv, nws tuaj yeem txhim kho myocardial ischemia, tiv thaiv cardiomyocytes, thiab txo cov kev pheej hmoo ntawm cov teeb meem plawv xws li arrhythmia thiab lub plawv tsis ua haujlwm.
V. Adjunctive Treatment of Graft-Versus-Host Disease and Reduction of Immune Damage
Graft-vim-tus kab mob (GVHD) yog ib qho teeb meem loj tom qab hloov cov qia cell. Nws yog tshwm sim los ntawm tus neeg pub lub cev tiv thaiv kab mob tawm tsam tus neeg tau txais cov ntaub so ntswg thiab lub cev, uas tuaj yeem koom nrog ntau yam xws li daim tawv nqaij, plab hnyuv, thiab daim siab, cuam tshuam rau tus neeg mob txoj sia nyob. Txawm hais tias hyperbaric oxygen tsis tuaj yeem ncaj qha thaiv lub cev tiv thaiv kab mob ntawm GVHD, nws tuaj yeem pab tswj GVHD cov tsos mob los ntawm kev kho cov ntaub so ntswg puas thiab txo cov lus teb inflammatory. Rau cutaneous GVHD, hyperoxia tuaj yeem txhawb kev tsim kho ntawm cov tawv nqaij puas hlwb thiab txo cov tsos mob xws li pob khaus, rwj, thiab khaus; rau plab hnyuv GVHD, nws muaj peev xwm ua kom ceev kho ntawm plab hnyuv mucosa, alleviate manifestations xws li raws plab, mob plab, thiab gastrointestinal los ntshav. Nyob rau tib lub sijhawm, nws muab lub hauv paus zoo dua rau cov neeg mob kom zam tau cov tshuaj kho mob xws li tshuaj tiv thaiv kab mob thiab txhim kho cov txiaj ntsig kho ntawm GVHD.
VI. Txhim kho Zuag qhia tag nrho Rehabilitation zoo thiab txo qhov kev pheej hmoo ntawm ntev -Lub sij hawm Sequelae
Tom qab hloov cov cell, cov neeg mob tsis tau tsuas yog ntsib kev hem thawj ntawm luv- lub sij hawm teeb meem tab sis kuj yuav raug kev txom nyem los ntawm lub sij hawm ntev - lub sij hawm sequelae xws li qaug zog, kev txawj ntse poob, thiab lub cev tsis ua hauj lwm vim ntev - lub sij hawm ischemia thiab hypoxia thiab cov ntaub so ntswg puas, cuam tshuam rau lub neej zoo. Los ntawm kev txhim kho cov pa oxygen tsis tu ncua, kho cov ntaub so ntswg puas, thiab tswj cov metabolism hauv lub cev, hyperbaric oxygen therapy tuaj yeem pab cov neeg mob rov qab lub cev lub zog sai dua thiab txo qis cov tsos mob qaug zog tom qab. Nyob rau tib lub sijhawm, nws txoj kev tiv thaiv ntawm lub paj hlwb, kab mob plawv, thiab lwm yam, tuaj yeem txo qhov tshwm sim ntawm -lub sij hawm sequelae thiab pab cov neeg mob rov qab mus rau lub neej zoo thiab ua haujlwm zoo dua.